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MR Vol.11 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.1 |
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Clinical and immunological features of systemic
lupus erythematosus complicated by Jaccoud's arthropathy |
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| M. Takeishi1, A. Mimori1, T. Suzuki1 |
| (1)Division of Rheumatology, Saitama Medical
School, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495,
Japan |
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| Abstract |
| Abstract This work was undertaken to evaluate
clinical and immunological features in patients with systemic lupus
erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients
diagnosed with SLE between 1985 and 1999, and who met the criteria
of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical
features were retrospectively analysed for patients with both diseases.
Sjogren's syndrome and human leukocyte antigens (HLA) in these patients
were evaluated. Jaccoud's arthropathy was found in 15 (4.4%) of 340
patients with SLE. The mean age at the time of SLE diagnosis was
significantly higher in these patients than in our control SLE patients,
which was 51.2 - 13.0 years (n = 15) and 29.6 - 13.0 years (n = 222)
(p = 2.1 2 10m8). Sjogren's syndrome was diagnosed according to the
European Community Study Group's criteria in 10 (91%) of 11 patients
examined. The incidence of HLA-A11 (5/9, 55%) and -B61(40) (5/9,
55%) in patients with Jaccoud's arthropathy was higher in the Japanese
population (A11, 17.4%, p < 0.05; B61, 17.5%, p < 0.057. Jaccoud's
arthropathy in patients with SLE is associated with Sjogren's syndrome,
elderly SLE, HLA-A11, and HLA-B61. These clinical features might
be characteristic of patients with Jaccoud's arthropathy and SLE. |
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| Key words |
| Key words HLA ・ Jaccoud's arthropathy ・ Sjogren's
syndrome ・ Systemic lupus erythematosus (SLE) |
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