 |
MR Vol.11 No.1 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.11 No.1 |
 |
|
|
 |
|
|
The possible role of c-fos expression in rheumatoid
joint destruction |
|
|
| M. Tsuji1, M. Tanaka1, H. Hayashi1, S.
Koshiishi1, K. Fujii1 |
| (1)Department of Orthopaedic Surgery, The Jikei
University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku,
Tokyo 105-8461, Japan |
| |
| Abstract |
| Abstract At present, although the etiology of
rheumatoid arthritis (RA) remains unknown, most investigators believe
that it is primarily an inflammatory disease of the synovial membrane
of the joints. However, we have recently focused on the pathology
of the early changes in articular cartilage and subchondral bone
in RA patients, and have shown that RA involves articular cartilage
and subchondral bone, not synovia. This research direction may lead
to the development of a new specific treatment for the disease. |
| |
| Key words |
| Key words Autoimmunity ・ c-fos ・ Rheumatoid
arthritis ・ TRAP-positive multinucleated cell ・ Type II collagen |
|
|
 |
|
|
