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MR Vol.11 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.1 |
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The SCID-HuRAg mouse as a model for rheumatoid
arthritis |
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| H. Matsuno1, K. Yudoh1, M. Uzuki2, T. Kimura1 |
(1)Department of Orthopedic Surgery, Toyama
Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194,
Japan Tel. +81-76-434-7351; Fax +81-76-434-5035 e-mail: matsuno@ms.toyama-mpu.ac.jp
(2)Department of Pathology, Iwate Medical University, Morioka, Japan |
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| Abstract |
| Abstract Many animal models have been developed
for a study of rheumatoid arthritis (RA). However, RA animal models
are not always similar to RA patients in their response to antirheumatic
drugs. Recently, humanized monoclonal antibody (mAb) has been developed
for the treatment of RA, but at present there is no animal model
on which to screen this mAb therapy because of problems with cross-reactivity.
We therefore considered the development of a novel animal model for
the screening of antirheumatic drugs using the severe combined immunodeficiency
(SCID) mouse in order to prevent the rejection of human transplant
cells. Following subcutaneous implantation of synovial tissue in
the SCID mouse, all target cells within the SCID-HuRAg mouse were
of human origin, having migrated from the implanted tissue. Moreover,
human interlukin-6 and rheumatoid factor were detected in this mouse
serum. We therefore propose that this SCID-HuRAg mouse is a novel,
useful animal model for the study and development of new drugs for
RA patients. This novel RA animal model is reviewed in this chapter. |
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| Key words |
| Key words Animal model ・ Monoclonal antibody
・ Rheumatoid arthritis ・ SCID mouse ・ Treatment |
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