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MR Vol.10 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.4 |
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Histopathological characteristics of early rheumatoid
arthritis: a case one month after clinical onset |
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| J. Kamogawa , N. Takubo3, N. Arita1, K. Okada1,
H. Yamamoto2, S. Yamamoto3, M. Nose1 |
(1)Department of Pathology, Ehime University
School of Medicine, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
(2)Department of Orthopedics, Ehime University School of Medicine, Ehime, Japan
(3)Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Ehime, Japan |
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| Abstract |
| Abstract A 68-year-old woman with early rheumatoid
arthritis (RA) was admitted to the hospital because of tender and
swollen knee joints. We performed a targeted synovial biopsy under
arthroscopy to examine the histopathological characteristics 1
month after clinical onset. The synovia showed the typical histopathology
of RA. Although the inflammatory changes were predominantly limited
to the surface area of the synovia, associated with neovascularization
and cell infiltrates composed mainly of T cells, plasma cells,
and macrophages, lesions with fibrin deposition, mesenchymoid transformation
and/or immature lymphoid follicles were also observed in part,
indicating that this case was in the progression phase of RA. What
we regularly call "early" might be "too late" even
if it is within 1 month of clinical onset. |
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| Key words |
| Key words Rheumatoid synovitis ・ Targeted
biopsy ・ Immunohistochemistry |
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