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MR Vol.10 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.4 |
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Thrombotic microangiopathic hemolytic anemia
in systemic lupus erythematosus associated with antiphospholipid
antibodies: usefulness of monitoring coagulation-fibrinolysis markers |
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| Y. Asanuma1, Y. Suzuki2, Y. Yasumuro3,
Y. Ichikawa2 |
(1) Institute of Medical Science, St. Marianna
University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki
216-8512, Japan Tel. +81-44-977-8111(ext 4267); Fax +81-44-977-4061
e-mail: fwkp2384@mb.infoweb.ne.jp
(2)Department of Internal Medicine, St. Marianna University School of Medicine,
Kawasaki, Japan
(3)Clinical Laboratory, St. Marianna University School of Medicine, Kawasaki,
Japan |
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| Abstract |
| Abstract We report on a 24-year-old woman
with systemic lupus erythematosus and lupus anticoagulant who developed
chronic thrombotic microangiopathic hemolytic anemia. The patient
responded well to a combination of plasma exchange and anticoagulant
therapy. Changes in the molecular markers for coagulation and fibrinolysis
corresponded with the disease activity. We suggest that thrombotic
microangiopathic hemolytic anemia should be suspected when anemia
and thrombocytopenia of unknown etiologies occur in systemic lupus
erythematosus. In such cases, the evaluation of molecular markers
for coagulation and fibrinolysis might be helpful both for diagnosis
and for assessing the response to therapy. |
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| Key words |
| Key words Hemolytic anemia ・ Systemic lupus
erythematosus ・ Antiphospholipid antibody ・ Plasma exchange ・ Molecular
markers for coagulation
and fibrinolysis |
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