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MR Vol.10 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.4 |
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Multicenter cooperative study of HLA class II
alleles in Japanese patients with systemic lupus erythematosus |
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| S. Morimoto1, H. Hashimoto1, K. Yamanaka1, Y.
Tokano1, Y. Nishimura2, S. Sawada3, N. Kamatani4, T. Sumida5, K.
Yoshizaki6, K. Nagasawa7, N. Miyasaka8 |
(1)Department of Rheumatology and Internal Medicine,
Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku,
Tokyo
(2)Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto
University Graduate School of Medical Science, Kumamoto, Japan
(3)Department of Medicine, Nihon University, Nerima Hikarigaoka Hospital, Tokyo,
Japan
(4)Institute of Rheumatology, Tokyo Woman's Medical College, Tokyo, Japan
(5)Department of Medicine, Institute of Clinical Medicine, University of Tsukuba,
Ibaraki, Japan
(6)Department of Third Medicine, Osaka University, Osaka, Japan
(7)Department of Internal Medicine, Saga Medical School, Saga, Japan
(8)Department of First Medicine, Tokyo Medical and Dental University, Tokyo,
Japan |
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| Abstract |
| Abstract The relation between HLA class II
alleles and clinical findings were examined in Japanese patients
with systemic lupus erythematosus (SLE). In 284 patients with multicenter
SLE, HLA class II alleles were examined using the DNA typing method,
and the results were compared with the clinical findings. The frequency
of DRB1*0101 and DQB1*0501 significantly increased in male patients,
and that of DRB1*0803 significantly increased in patients over
50 years of age. In relation to cutaneous manifestations, there
were positive photosensitivity associations with DQA1*0101 and/or
DQA1*0301, malar rash with DQA1*0101 and/or DRB1*0901, alopecia
with DQA1*0101, skin ulcers with DRB1*0401, and oral ulcers with
DQA1*0301. In addition, there were also positive associations of
myalgia with DRB1*1406 and negative associations of aseptic bone
necrosis with DQA1*0601, and hepatomegaly with DRB1*0405 and/or
DQA1*0401. In relation to laboratory findings, there were positive
associations of hemolytic anemia with DRB1*1402 and negative associations
of leukopenia with DQA1*0601, lymphopenia with DQA1*0301, and proteinuria
with DRB1*0901. Interestingly, DQA1*0101 and/or DQB1*0501 were
significantly associated with WHO classification type II rather
than type IV. In patients with SLE, some HLA types related to clinical
or laboratory findings. |
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| Key words |
| Key words SLE ・ HLA ・ Lupus nephritis |
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