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MR Vol.10 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.4 |
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Identification of the proto-oncogene
c-fos in areas of periprosthetic osteolysis around loosened hip
prostheses |
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| C. Chiba1, J. Chiba1, M. Oyama1, K. Inoue1 |
| (1)Department of Orthopaedic Surgery, Daini
Hospital, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku,
Tokyo 116-8567, Japan |
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| Abstract |
| Abstract Expression of the proto-oncogene
c-fos was investigated by in situ hybridization and a study of
the immunohistochemistry of the interfacial membranes surrounding
the femoral component of failed cementless total hip arthroplasty
(THA). The values of the proto-oncogene c-fos gene and protein
were high in these interfacial membranes. High expression of the
c-fos gene and protein was observed in the macrophage-like cells
and fibroblast-like cells. However, there was little expression
in multinucleated giant cells. We demonstrated the significance
of the proto-oncogene c-fos in interfacial membranes - the first
report of c-fos in total joint replacement failure. |
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| Key words |
| Key words Proto-oncogene c-fos ・ Interfacial
membrane ・ Osteolysis |
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