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MR Vol.10 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.1 |
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Possible episodes that trigger thrombotic events
in patients with antiphospholipid syndrome |
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| K. Suzuki, T. Hidaka, T. Shinohara, M. Matsumoto,
M. Okada, K. Kataharada, F. Ohsuzu |
| (1)Internal Medicine I, National Defense
Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan |
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| Abstract |
| Abstract The presence of antiphospholipid antibodies
and/or lupus anticoagulant (LA) increase the risk of thrombosis,
while the onset of thrombosis is usually sudden. The objective of
this study was to determine whether or not some episodes triggered
thrombotic events in patients possessing antiphospholipid antibodies.
Fifteen patients who presented with thrombosis (primary antiphospholipid
syndrome (APS), six cases; secondary APS, nine cases) were retrospectively
examined to discover whether or not any specific episodes occurred
prior to a total of 21 thrombotic events. In five events occurring
in five female patients, specific episodes were identified, including
the wearing of tight underwear, dehydration due to fever and standing
in hot and humid weather, fever following the extraction of a carious
tooth, steroid pulse therapy, toxemia during pregnancy, and intrauterine
fetal death. To prevent the occurrence of thrombosis in patients
possessing antiphospholipid antibodies, it appears to be important
to avoid such triggering episodes and also to reduce the risk factors
for thrombosis. |
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| Key words |
| Key words Antiphospholipid syndrome ・ Thrombosis
・ Risk factor |
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