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MR Vol.10 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.10 No.1 |
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Interactions between T cells and synovial fibroblasts |
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| Y. Yamamura, E. Shelden, D. A. Fox |
(1)Division of Rheumatology, Department of
Internal Medicine, and Multipurpose Arthritis and Musculoskeletal
Diseases Center, University of Michigan, 5520 MSRBI, 1150 W. Medical
Center Drive, Ann Arbor, MI 48109-0680, USA
(2)Department of Anatomy and Cell Biology, University of Michigan, MI, USA |
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| Abstract |
| Abstract T lymphocytes, synovial macrophages,
and synovial fibroblasts are the three most abundant cell populations
in rheumatoid arthritis
synovial tissue, and each is believed to play an important role
in the pathogenesis of joint inflammation and destruction. While
interactions between T cells and macrophages and between macrophages
and fibroblasts have been carefully studied, less attention has
been paid to potential interactions between T lymphocytes and
synovial fibroblasts. In this review we consider available data
which suggests that cell-cell contact between T lymphocytes and
synovial fibroblasts may lead to activation of each cell type.
This interaction is likely to be significant in the pathophysiology
of rheumatoid arthritis. |
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