Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology

Vol.23 No.6

Review Article

Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology

Authors

Ce Dou¹ , Yanfei Yan¹ , Shiwu Dong¹

Department of Anatomy, Tissue Engineering Research Center of Chongqing, The Third Military Medical University, Gaotanyan Street No. 30, Chongqing, 400038, China

Received:

28 September 2012

Accepted:

26 November 2012

Published online:

14 December 2012

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Abstract

Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. Cadherin-11 is involved in the function of embryonic development, tissue morphogenesis, tumor invasion and metastasis, and signal transduction. This review summarizes the function of cadherin-11 in synovial joint formation and rheumatoid arthritis (RA), including its relative function with bone and cartilage development and growth plate, synovial, and tendon formation. The role of cadherin-11 in RA is also discussed, both in fibroblasts inflammation and fibroblast-like synoviocyte (FLSs) migration and invasion. The potential of anti-cadherin-11 therapy for RA is introduced in comparison with the other current RA therapies.

Key words

Cadherin-11, Cell adhesion, Chondrocytes, Rheumatoid arthritis, Synovial joint formation