Vol.23 No.5

Original Article

CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Authors

Giulia Pazzola1 , Luigi Boiardi1 , Bruno Casali2 , Enrico Farnetti2 , Davide Nicoli2 , Nicol? Pipitone1 , Ilaria Padovano1 , Andrea Caruso1 , Mariagrazia Catanoso1 , Carlo Salvarani1, 3

  • Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy
  • Molecular Biology Laboratory, Department of Oncology, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy
  • Servizio di Reumatologia, Azienda Ospedaliera ASMN-IRCCS, Viale Risorgimento 80, 42123, Reggio Emilia, Italy
Received:

30 May 2012

Accepted:

17 August 2012

Published online:

23 September 2012

Full Text

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Abstract

Objectives To evaluate the potential role of CC chemokine receptor 5 (CCR5)D32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.
Methods 176 consecutive Italian patients with biopsyproven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5D32 polymorphism.
Results No statistically significant difference in the D32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5D32 allele (D32/D32 ? CCR5/D32) were similarly represented in the two groups.
Conclusions Our results do not support a role for the CCR5D32 polymorphism in determining susceptibility to GCA.

Key words

CC chemokine receptor 5 Δ32 polymorphism, Giant cell arteritis