Vol.23 No.4

Original Article

Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis

Authors

Man-Man Lu1, 3 , Wang-Dong Xu1, 2 , Jie Yang1, 2 , Qian-Ling Ye4 , Chen-Chen Feng1, 2 , Jing Li1, 2 , Hai-Feng Pan1, 2 , Jin-Hui Tao5 , Jing Wang1, 2 , Dong-Qing Ye1, 2

  • Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China
  • Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, People’s Republic of China
  • School of Health Administration, Anhui Medical University, Hefei, People’s Republic of China
  • The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, People’s Republic of China
  • Department of Rheumatology and Immunology, Anhui Provincial Hospital, Hefei, 230001, Anhui, People’s Republic of China
Received:

29 March 2012

Accepted:

14 June 2012

Published online:

1 August 2012

Full Text

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Abstract

Introduction To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) risk, we surveyed studies on the association of the TNFSF4 rs2205960, rs1234315, rs844644, and rs844648 polymorphisms with SLE.
Methods A literature-based search was conducted to identify all relevant studies. A total of eight independent studies were identified and subsequently reviewed in the meta-analysis.
Results The meta-analysis showed an association between the TNFSF4 rs2205960 polymorphism and SLE in all subjects [ odds ratio (OR) 1.327, 95 % confidence interval (CI) 1.227?1.436, P%ABST%.001]. In a subgroup analysis by ethnicity, a significantly increased risk for SLE was associated with TNFSF4 rs2205960 T allele among patients of European (OR 1.254, 95 % CI 1.185?1.328, P%ABST%.001) and Asian ethnicity (OR 1.425, 95 % CI 1.352?1.501, P%ABST%.001). The meta-analysis of the rs1234315 polymorphism revealed no association between SLE and the rs1234315 T allele in all subjects (OR 1.167, 95 % CI 0.874?1.558, P = 0.296), but the results of the subgroup analysis revealed significant association in subjects of Asian ethnicity (OR 1.386, 95 % CI 1.318?1.458, P%ABST%.001). No association was found between the rs844644 and rs844648 polymorphisms and SLE.
Conclusion The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.

Key words

Tumor necrosis factor ligand superfamily member 4, OX40L, Genetic polymorphisms, Systemic lupus erythematosus, Meta-analysis