Vol.23 No.3

Case Report

Successful treatment with tocilizumab in a case of Cogan’s syndrome complicated with aortitis

Authors

Mihoko Shibuya1 , Keishi Fujio1 , Kaoru Morita1 , Hiroaki Harada1 , Hiroko Kanda1 , Kazuhiko Yamamoto1

  • Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Received:

20 April 2012

Accepted:

30 May 2012

Published online:

1 July 2012

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Abstract

A 69-year-old man with sensorineural hearing loss and iritis was diagnosed with atypical Cogan’s syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis and seronegative arthritis. Remission induced by treatment with high doses of prednisolone was followed by relapse within 1 year. Although his condition was resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine and adalimumab, his symptoms, inflammatory response and quality of life measures were successfully improved by tocilizumab, a humanized anti-interleukin-6 receptor antibody.

Key words

Cogan’s syndrome, Aortitis, Tocilizumab, IL-6