Vol.23 No.3

Case Report

A case of ANCA-associated vasculitis with glomerular eosinophilic infiltration: a possible pathogenic implication

Authors

Hiroko Suzuki1 , Takayuki Fujita1 , Yoshinobu Fuke1 , Minako Yabuki1 , Mamiko Kajiwara1 , Yuko Ishihara1 , Seiichiro Hemmi1 , Masayoshi Soma1

  • Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashiku, Tokyo 173-8610, Japan
Received:

15 March 2012

Accepted:

21 May 2012

Published online:

19 June 2012

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Abstract

We present a 58-year-old male patient with myeloperoxidase antineutrophil cytoplasmic antibodyassociated vasculitis with rapidly progressive glomerulonephritis. He failed to fulfill the common American College of Rheumatology criteria for eosinophilic granulomatosis with polyangiitis and was tentatively diagnosed with microscopic polyangiitis. Kidney biopsy showed pauciimmune crescentic necrotizing glomerulonephritis with neutrophilic and eosinophilic infiltration. Previous reports implicate eosinophils in the pathogenesis of this disease. Therefore, this case suggests that infiltrated eosinophils as well as neutrophils might play roles in the development of tissue injury in systemic vasculitis.

Key words

Myeloperoxidase antineutrophil cytoplasmic antibody (MPO?ANCA), Glomerular eosinophilic infiltration, Eosinophilic granulomatosis with polyangiitis (EGPA), Microscopic polyangiitis (MPA), Pauci-immune crescentic necrotizing glomerulonephritis