Vol.23 No.3

Case Report

Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Authors

Nobuyuki Ono1 , Kyoko Yoshihiro1 , Daisuke Oryoji1 , Motohiro Matsuda1 , Yoshihiro Ueki2 , Shigehiro Uezono1 , Yasufumi Kai1 , Daisuke Himeji1 , Hiroaki Niiro3 , Akira Ueda1

  • Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu-cho, Miyazaki Miyazaki, 880-8510, Japan
  • Department of Otolaryngology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan
  • Department of Clinical Immunology and Rheumatology/Infectious Disease, Kyushu University Hospital, Fukuoka, Japan
Received:

13 December 2011

Accepted:

14 May 2012

Published online:

17 June 2012

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Abstract

Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.

Key words

MPO-ANCA, Vasculitis, Otitis media, Epidemiology, ANCA-associated vasculitis