Vol.23 No.3

Original Article

Effects of adalimumab therapy on musculoskeletal manifestations and health-related quality of life in patients with active psoriatic arthritis

Authors

Shigeyoshi Tsuji1 , Mari Higashiyama2 , Masahiro Inaoka3 , Tetsuya Tomita4 , Akinori Yokomi2 , Ayako Satoh2 , Ayuko Hirano2 , Misa Hayashi2 , Maki Tsuji2 , Yasuo Kunugiza4 , Masayuki Hamada1 , Hideki Yoshikawa4

  • Department of Orthopaedic Surgery, Hoshigaoka Koseinenkin Hospital, 4-8-1 Hoshigaoka, Hirakata Osaka, 573-8511, Japan
  • Department of Dermatology, Nissay Hospital, Osaka, Japan
  • Department of Orthopaedic Surgery, Nissay Hospital, Osaka, Japan
  • Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Japan
Received:

8 February 2012

Accepted:

11 June 2012

Published online:

1 July 2012

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Abstract

Objectives Adalimumab, a fully human anti-tumor necrosis factor monoclonal antibody, was retrospectively evaluated for its effect on musculoskeletal manifestations and health-related quality of life in patients with psoriatic arthritis (PsA) during daily clinical practice.
Methods Patients who initiated adalimumab therapy after March 2010 were followed for at least 24 weeks with the clinical outcome measures. Eleven patients, all men with a mean age of 45.4 years, had mean psoriasis durations of 16.2 and 8.4 years at baseline.
Results After 24 weeks, 72.7, 63.6, and 45.5 % of the patients met the ACR 20, 50, and 70 response criteria, respectively, while 81.8 % achieved the PsA response criteria. Disease Activity Score using the 28-joint count and CRP declined from 3.2 ± 1.2 at baseline to 1.3 ± 0.4 at week 24 (P%ABST%.01). The Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index scores also decreased significantly (both P values were%ABST%.01). After 24 weeks, three out of eight dimensions of the Medical Outcomes Study 36-Item Short Form Health Survey and Physical Component Summary were significantly improved (all P values were%ABST%.05).
Conclusions Adalimumab exerted its effect as early as week 4, and it was sustained until the end of the 24-week observation period in the PsA patients.

Key words

Adalimumab, Biologics, Methotrexatel, Psoriasis, Psoriatic arthritis