Vol.23 No.2

Case Report

Successful treatment of osteomalacia caused by renal tubular acidosis associated with Sjögren’s syndrome

Authors

Sunao Yamamoto1 , Yosuke Okada1 , Hiroko Mori1 , Shintaro Hirata1 , Kazuyoshi Saito1 , Nobuo Inokuchi2 , Yoshiya Tanaka1

  • The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan
  • Inokuchi Clinic, 10-6 Yoshino-cho, Kokurakita-ku, Kitakyusyu, 802-0085, Japan
Received:

7 March 2012

Accepted:

8 May 2012

Published online:

28 June 2012

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Abstract

A 62-year-old woman was diagnosed with severe osteomalacia caused by renal tubular acidosis associated with Sjögren’s syndrome. She was treated with sodium bicarbonate, risedronate, alfacalcidol, and prednisolone (1 mg/kg). By 24 months, renal tubular acidosis was improved and the bone density had normalized. Here we report the successful amelioration of bone lesions through a multidisciplinary approach that improved renal tubular acidosis, with a special focus on treatment of the underlying inflammatory disorder with glucocorticoids.

Key words

Distal renal tubular acidosis - Glucocorticoid - Osteomalacia - Sjögren’s syndrome