Vol.23 No.2

Original Article

Association between transforming growth factor-α polymorphism and ankylosing spondylitis: a meta-analysis update

Authors

Chencheng Wang¹ , Hong Su¹ , Weiwei Chang¹ , Zhiwei Xu¹ , Qin Han¹ , Xiaowei Shan¹

Received:

20 September 2011

Accepted:

16 April 2012

Published online:

2 June 2012

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Abstract

Objectives The reported results of the relationship between genetic polymorphisms of tumor necrosis factor (TNF)-α -238, -308 locus and ankylosing spondylitis (AS) susceptibility are not always consistent. This article aims to perform a meta-analysis to collect all the relevant studies to date to further clarify the relationship between those genetic polymorphisms and AS.
Methods A computer search was carried out up to September 2011 for literature pertaining to AS and TNF-α polymorphisms.
Results Twenty-two articles were included, with 2,506 cases of AS and 3,023 normal controls. We searched for genotypes A allele vs. G allele, AA vs. GG + GA, and GA + AA vs. GG in a fixed/random-effects model. The effect summary odds ratios (ORs) and 95 % confidence intervals (CIs) were obtained, which shows there was no association between genetic polymorphisms and AS. As the heterogeneity was observed, in a subgroup analysis by ethnicity, the degree of risk of two genes with AS susceptibility was similar in populations of European and Asian origin. For the human leukocyte antigen (HLA)-B27+ population, results were not statistically significant.
Conclusion ORs of various comparisons indicate that there is no association between TNF-α -238, -308 polymorphisms and AS susceptibility in the overall population and in the subgroup of Asian and non-Asian descent.

Key words

Ankylosing spondylitis - Genetic polymorphisms - Meta-analysis - Tumor necrosis factor-α