Vol.23 No.2

Original Article

Major depressive disorder in patients with rheumatoid arthritis

Authors

Eri Sato1 , Katsuji Nishimura2 , Ayako Nakajima1 , Hiroshi Okamoto1 , Mikiko Shinozaki1 , Eisuke Inoue1 , Atsuo Taniguchi1 , Shigeki Momohara1 , Hisashi Yamanaka1

  • Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan
  • Department of Psychiatry, Tokyo Women’s Medical University, Tokyo, Japan
Received:

8 December 2011

Accepted:

23 March 2012

Published online:

23 May 2012

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Abstract

Objective To investigate the point prevalence of major depressive disorder (MDD) as diagnosed by the Mini-International Neuropsychiatric Interview (M.I.N.I) in patients with rheumatoid arthritis (RA) and to determine whether MDD is related to features of RA disease, such as disease activity or physical dysfunction.
Methods Of the patients with RA who participated in the IORRA survey conducted in October 2005, 162 were evaluated using the M.I.N.I., the Center for Epidemiologic Studies-Depression (CES-D) scale, and the two-question depression screen for MDD. RA clinical features were obtained from the concomitant IORRA cohort database. Relationships between MDD and RA disease features were analyzed by the Wilcoxon rank sum test and Pearson’s chisquare test.
Results The point prevalence of MDD as diagnosed by the M.I.N.I. was 6.8 % in our Japanese patients with RA. The percentage of depressive patients was determined to be 23.5, 17.3, or 7.4 % according to the CES-D scale with cutoff points of 16, 19, or 27, respectively, and 14.2 % according to the two-question depression screen. The best cut-off point for CES-D for risk of MDD diagnosed by M.I.N.I. in this study was determined to be 23, with 11.7 % depressive patients having the highest sum of sensitivity and specificity. No relationship between MDD and RA disease activity was detected.
Conclusion By using the well-established structural interview instrument M.I.N.I., we determined the point prevalence of MDD in the RA patients enrolled in this study to be 6.8 %, leading to the conclusion that concomitant MDD does not seem to influence disease activity in RA patients.

Key words

Rheumatoid arthritis - Major depressive disorder - Mini-International Neuropsychiatric Interview - Prevalence - Center for Epidemiologic Studies-Depression Scale