Vol.23 No.1

Case Report

A case of aseptic abscesses syndrome treated with corticosteroids and TNF-alpha blockade

Authors

Tomoyuki Ito1 , Naoko Sato1 , Hajime Yamazaki1 , Tadashi Koike1 , Iwao Emura2 , Takako Saeki1

  • Department of Internal Medicine, Nagaoka Red Cross Hospital, 2-297-1 Senshu, Nagaoka, Niigata, 940-2085, Japan
  • Department of Pathology, Nagaoka Red Cross Hospital, 2-297-1 Senshu, Nagaoka, Niigata, 940-2085, Japan
Received:

27 December 2011

Accepted:

22 March 2012

Published online:

20 April 2012

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Abstract

Aseptic abscesses syndrome (AA) is an emerging clinicopathological entity characterized by visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids. Although most previous case reports of AA have been restricted to Europe, we present here a Japanese woman with AA showing recurrence of splenic abscesses, ileocolitis, pyoderma gangrenosum, and arthritis. Although both steroid therapy and tumor necrosis factor (TNF)-alpha blockade were effective, relapses remained frequent.

Key words

Aseptic abscess - Steroid - TNF-alpha blockade - Pyoderma gangrenosum - Autoinflammatory disorder