Vol.23 No.1

Case Report

Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases

Authors

Yoshiro Horai1 , Eriko Isomoto2 , Tomohiro Koga1 , Akitomo Okada1 , Shin-ya Kawashiri1 , Mami Tamai1 , Satoshi Yamasaki1 , Hideki Nakamura1 , Tomoki Origuchi1,3 , Yasuhito Hamaguchi4 , Manabu Fujimoto4 , Masataka Kuwana5, Atsushi Kawakami1

  • Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
  • The Japanese Red Cross Nagasaki Genbaku Hospital, Morimachi 3-15, Nagasaki, 852-8511, Japan
  • Nagasaki University School of Health Sciences, Nagasaki, Japan
  • Department of Dermatology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan
  • Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan
Received:

17 January 2012

Accepted:

12 March 2012

Published online:

30 March 2012

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Abstract

We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron’s papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including steroid pulse therapy, resulting in significant improvement in respiratory symptoms, clinical data, and imaging. Measurement of anti-CADM-140/MDA5 antibody was useful for obtaining a definitive diagnosis of CADM in these cases.

Key words

Amyopathic dermatomyositis - Anti-CADM-140/MDA5 antibody - Interstitial lung disease - Prognosis