Vol.23 No.1

Case Report

A case of chronic active Epstein-Barr virus infection mimicking adult-onset Still’s disease

Authors

Katsunobu Yoshioka1 , Hiroko Fukushima2 , Naomi Ishii2 , Akiko Kita3 , Yusuke Hanioka3 , Mieko Minami1 , Takeshi Inoue2 , Keiko Yamagami3

  • Department of Internal Medicine, Osaka City Sumiyoshi Hospital, 1-2-16 Higashikagaya, Suminoeku, Osaka, Osaka, 559-0012, Japan
  • Department of Pathology, Osaka City General Hospital, Osaka, Japan
  • Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan
Received:

22 November 2011

Accepted:

13 February 2012

Published online:

28 February 2012

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Abstract

An 83-year-old man was diagnosed with adultonset Still’s disease (AOSD) based on clinical and laboratory findings. However, glucocorticoid had little effect. Epstein?Barr virus (EBV)-DNA was detected in peripheral blood, and autopsy findings confirmed a diagnosis of chronic active EBV infection (CAEBV). CAEBV mimics AOSD, and the presence of articular involvement and leukocytosis does not exclude the possibility of CAEBV. CAEBV should be included in the differential diagnosis of AOSD, and measurement of EBV-DNA is essential.

Key words

Chronic active Epstein-Barr virus infection - Adult-onset Still’s disease - Hemophagocytic syndrome