Vol.22 No.6

Case Report

A case of IgG4-related pulmonary disease with rapid improvement

Authors

Masataka Umeda1 , Keita Fujikawa1 , Tomoki Origuchi2 , Toshiaki Tsukada1 , Akira Kondo3 , Shinya Tomari3 , Yuichi Inoue3 , Hisashi Soda4 , Hideki Nakamura5 , Shoko Matsui6 , Atsushi Kawakami5

  • Department of Rheumatology, Isahaya Health Insurance General Hospital, 24-1 Eishohigashi-machi, Isahaya, Nagasaki, Japan
  • Department of Rehabilitation Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8520, Japan
  • Department of Respirology, Isahaya Health Insurance General Hospital, 24-1 Eishohigashi-machi, Isahaya, Nagasaki, Japan
  • Department of Internal Medicine, Isahaya Health Insurance General Hospital, 24-1 Eishohigashi-machi, Isahaya, Nagasaki, Japan
  • Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, Japan
  • Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
Received:

18 November 2011

Accepted:

16 January 2012

Published online:

5 February 2012

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Abstract

We report a 72-year-old man with respiratory involvement of immunoglobulin G4 (IgG4)-related disease, who developed dry cough and shortness of breath on effort. The chest computed tomography scan image showed massive and diffuse ground-glass opacity, interlobular thickening, and bronchial wall thickening. The infiltration of IgG4-positive plasma cells in the transbronchial lung biopsy and high serum IgG4 concentrations were found. The patient was treated with 0.6 mg/kg oral prednisolone and showed rapid improvement. This is a case of IgG4-related disease in which the only complication was respiratory involvement.

Key words

IgG4-related disease - Interstitial pneumonia - Respiratory involvement