Vol.21 No.5

Case Report

Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus

Authors

Yoshishige Miyabe1 , Yutaka Murata1 , Yukari Baba2 , Eisaku Ito3 , Kenji Nagasaka1

  • Department of Rheumatology, Ome Municipal General Hospital, 4-16-5 Higashi-Ome, Ome, Tokyo, 198-0042, Japan
  • Department of Dermatology, Ome Municipal General Hospital, Ome, Tokyo, Japan
  • Department of Surgical Pathology, Ome Municipal General Hospital, Ome, Tokyo, Japan
Received:

16 November 2010

Accepted:

14 February 2011

Published online:

6 March 2011

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Abstract

A 34-year-old woman with discoid lupus erythematosus and lupus profundus was admitted to our hospital showing signs of a fever, malaise, and abdominal swelling. Diagnosis of cytophagic histiocytic panniculitis (CHP) was made based on lobular panniculitis with a hemophagocytosis. Treatment with high doses of prednisolone combined with cyclosporine A (CsA) was not effective enough. However, after changing CsA to tacrolimus (TAC), CHP improved. Our case demonstrates that TAC may be a novel therapy for CHP.

Key words

Cytophagic histiocytic panniculitis - Tacrolimus - Cyclosporine A