Vol.21 No.5

Case Report

Successful treatment of a patient with IgG4-related disease with a paravertebral mass lesion

Authors

Hideki Nakamura1 , Keiko Hisatomi2 , Tomohiro Koga1 , Akinari Mizokami2 , Satoshi Yamasaki1 , Mami Tamai1 , Tomoki Origuchi1 , Junji Irie3 , Atsushi Kawakami1

  • Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki, 852-8501, Japan
  • Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan
  • Department of Pathology, Nagasaki Municipal Hospital, Nagasaki, Japan
Received:

5 January 2011

Accepted:

31 January 2011

Published online:

19 February 2011

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Abstract

A 68-year-old woman was admitted with bleary eyes and lacrimal gland swelling. A biopsy specimen from a right paravertebral mass lesion detected by computed tomography showed remarkable IgG4-positive plasma cells. Because serum IgG4 was elevated to 3300 mg/dl, IgG4-related disease was diagnosed, with the assistance of fluorodeoxyglucose positron emission tomography (FDGPET)/computed tomography (CT). Administration of 30 mg of oral prednisolone effectively reduced the lacrimal gland swelling and paravertebral mass volume. Nine months after the initiation of prednisolone, serum IgG4 was reduced to 31.4 mg/dl, and there was norecurrence.

Key words

IgG4 - Immunohistochemistry - Paravertebral mass