Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus
Yuichiro Fujieda1 , Hiroshi Kataoka1 , Toshio Odani1 , Kotaro Otomo1 , Masaru Kato1 , Shinji Fukaya1 , Kenji Oku1 , Tetsuya Horita1 , Shinsuke Yasuda1 , Tatsuya Atsumi1 , Takao Koike1
12 August 2010
4 November 2010
12 January 2011
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To characterize reversible posterior leukoencephalopathy syndrome (RPLS) in systemic lupus erythematosus (SLE) in terms of treatments for resolution and its clinical course, we reviewed 28 cases of RPLS in SLE including our cases in view of the treatment. Of these, 15 cases improved with blood pressure control and 13 required immunosuppressive therapy for activity of SLE presenting neurological manifestations. Patients without immunosuppressants at onset of RPLS more frequently required immunosuppressive therapy to recover it than those precedingly using these agents [31% (4/13) versus 87% (13/15), p = 0.008, chi-square test]. Brain magnetic resonance imaging (MRI) is important for diagnosis of RPLS-SLE in the patient with SLE who develops neurological disturbance and rapidly increasing blood pressure. When 7-day therapy for hypertension and convulsion does not reverse the manifestations, immunosuppressive treatments would be recommended to reverse RPLS.
Reversible posterior leukoencephalopathy syndrome (RPLS) - Systemic lupus erythematosus (SLE) - Neuropsychiatric systemic lupus erythematosus (NPSLE) - Magnetic resonance imaging (MRI)