Vol.21 No.2

Case Report

A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level

Authors

Go Muto1 , Yuko Takahashi1 , Hiroyuki Yamashita1 , Akio Mimori1

  • Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan
Received:

30 April 2010

Accepted:

7 September 2010

Published online:

8 October 2010

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Abstract

A 74-year-old woman presented with multiple brain infarctions, an inflammatory reaction, and a high serum titer (414 U/ml) of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA) with no hematological abnormalities. After the inflammation and ANCA titers were resolved with steroid therapy for suspected microscopic polyangiitis, hemophagocytic syndrome developed. Biopsies revealed non-Hodgkin’s intravascular lymphoma (IVL). The flare of IVL with negative serum ANCA suggested that the initial high serum MPO-ANCA had not originated from tumor cells.

Key words

Antineutrophil cytoplasmic antibody - MPO-ANCA - Intravascular lymphoma