Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus

Vol.21 No.1

Case Report

Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus

Authors

Koichiro Suemori¹ , Hitoshi Hasegawa¹ , Chika Nanba² , Masashi Kohno¹ , Takuya Matsumoto¹ , Yusuke Kawamoto¹ , Shinji Murakami² , Eiji Sada³ , Koji Hashimoto² , Masaki Yasukawa¹

Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine
Department of Dermatology, Ehime University Graduate School of Medicine
Department of Medical Technology, Ehime Prefectural University of Health Sciences

Received:

6 November 2009

Accepted:

4 August 2010

Published online:

26 August 2010

Full Text

PDF　(member's only)

Abstract

We describe the first reported case of a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by low-dose tacrolimus in a patient with autoimmune disease. A 41-year-old man with systemic lupus erythematosus (SLE) developed hyponatremia induced by SIADH after administration of tacrolimus (0.06 mg/kg per day). In this case, the hyponatremia promptly resolved upon withdrawal of tacrolimus. This case strongly suggests that SIADH is a potentially important complication of tacrolimus administration, irrespective of dosage, and should be borne in mind whenever the drug is used.

Key words

Hyponatremia - Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) - Systemic lupus erythematosus (SLE) - Tacrolimus