Vol.20 No.6

Case Report

An attack of acute neuro-Behçet’s disease during the course of chronic progressive neuro-Behçet’s disease: report of two cases

Authors

Toshimichi Matsui1 , Takashi Ishida1 , Toshihiro Tono1 , Takuhiro Yoshida2 , Shun-ichi Sato2 , Shunsei Hirohata1

  • Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan
  • Department of Neurology, Nagano Red-Cross Hospital, Nagano, Japan
Received:

15 March 2010

Accepted:

14 June 2010

Published online:

9 July 2010

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Abstract

A 29-year-old man and a 36-year-old man developed attacks of acute neuro-Behçet’s disease (NB) (right Horner’s syndrome and right hemiplegia and dysarthria, respectively) during the course of chronic progressive NB (acute on chronic). Although both patients recovered from acute NB after treatment with infliximab or corticosteroids, they continued to show manifestations of chronic progressive NB. It is suggested that acute NB and chronic progressive NB are different in their pathogenesis.

Key words

Infliximab - IL-6 - Cerebrospinal fluid - Magnetic resonance imaging