Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine

Vol.20 No.6

Case Report

Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine

Authors

Satoru Akazawa¹ , Kunihiro Ichinose¹ , Tomoki Origuchi² , Shin-ya Kawashiri¹ , Naoki Iwamoto¹ , Keita Fujikawa¹ , Toshiyuki Aramaki¹ , Makoto Kamachi¹ , Kazuhiko Arima¹ , Mami Tamai¹ , Hideki Nakamura¹ , Hiroaki Ida¹, Atsushi Kawakami¹, Katsumi Eguchi¹

Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
Graduate School of Health Sciences, Nagasaki University, Nagasaki, Japan

Received:

17 March 2010

Accepted:

31 May 2010

Published online:

26 June 2010

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Abstract

A 36-year-old female patient who was diagnosed with chronic myocarditis as an initial manifestation of systemic lupus erythematosus (SLE) was admitted to our hospital. At her third occurrence of heart failure, we performed an endomyocardial biopsy and proved chronic myocarditis with SLE. Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her cardiac function improved. We describe for the first time treatment with MZR for chronic cardiac involvement of SLE.

Key words

SLE - Lupus myocarditis - Mizoribine