Vol.20 No.6

Original Article

Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis

Authors

Toru Doi1 , Tsuyoshi Miyazaki1 , Jinju Nishino2 , Sakae Tanaka3 , Toshihiro Matsui4 , Akiko Komiya4 , Seizo Yamamoto1 , Fumiaki Tokimura1 , Toshihito Mori5 , Keita Nishimura6 , Narutaka Katoh6 , Jun Hasegawa7, Yasunori Omata7, Takashi Matsushita6, Shigeto Tohma4

  • Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
  • Nishino Clinic Orthopedics and Rheumatology, 2-9-15 Nishigaoka, Kita-ku, Tokyo 115-0056, Japan
  • Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8605, Japan
  • Department of Rheumatology, Sagamihara National Hospital, National Hospital Organization (NHO), 18-1 Sakuradai, Sagamihara Kanagawa, 228-8522, Japan
  • Department of Orthopaedic Surgery, Sagamihara National Hospital, National Hospital Organization (NHO), 18-1 Sakuradai, Sagamihara Kanagawa, 228-8522, Japan
  • Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
  • Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, 2-9-2 Musashidai, Fuchu Tokyo, 183-8524, Japan
Received:

26 February 2010

Accepted:

11 May 2010

Published online:

15 June 2010

Full Text

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Abstract

The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation); p < 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis.

Key words

Arthritis - CD64 - Gout - Local infection - Pseudogout