Vol.20 No.4

Case Report

Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men

Authors

Tomoko Yokoyama1 , Takashi Usui1,2 , Kazuhiro Kiyama1 , Ran Nakashima1 , Naoichiro Yukawa1 , Daisuke Kawabata1 , Takaki Nojima1 , Koichiro Ohmura1 , Takao Fujii1 , Tsuneyo Mimori1

  • Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
  • Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Build. B, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Received:

7 January 2010

Accepted:

16 February 2010

Published online:

8 April 2010

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Abstract

We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.

Key words

Drug-induced lupus erythematosus - Ticlopidine - Anti-histone antibody