Vol.20 No.3

Case Report

Kikuchi-Fujimoto disease developed into autoimmune disease: a report of two cases

Authors

Shohei Ogata1 , Yuki Bando1 , Norimitsu Saito2 , Kensei Katsuoka2 , Masahiro Ishii1

  • Department of Pediatrics, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara Kanagawa, 228-0855, Japan
  • Department of Dermatology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara Kanagawa, 228-0855, Japan
Received:

2 July 2009

Accepted:

9 December 2009

Published online:

15 January 2010

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Abstract

We report herein the pathological findings and clinical courses of two cases of Kikuchi-Fujimoto disease (KFD) that developed into autoimmune diseases. The patients are currently undergoing treatment for a disease similar to Sjogren’s syndrome and systemic lupus erythematosus/mixed connective tissue disease. KFD is not an independent condition and most likely develops due to an autoimmune mechanism. Pediatricians should pay careful attention to KFD and encourage long-term follow-up in patients with this condition.

Key words

Kikuchi-Fujimoto disease - Histiocytic necrotizing lymphadenitis - Autoimmune disease - Systemic lupus erythematosus - Sjogren’s syndrome