Vol.20 No.3

Original Article

Impact of biologics on the prevalence of orthopedic surgery in the National Database of Rheumatic Diseases in Japan

Authors

Tetsuro Yasui1 , Jinju Nishino2 , Yuho Kadono1 , Toshihiro Matsui3 , Kozo Nakamura1 , Sakae Tanaka1 , Shigeto Tohma4

  • Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
  • Orthopaedic Surgeon, Nishino Clinic Orthopedics and Rheumatology, Tokyo 115-0056, Japan
  • Department of Rheumatology, Sagamihara National Hospital, National Hospital Organization (NHO), Kanagawa 228-8522, Japan
  • Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization (NHO), 18-1 Sakuradai, Sagamihara Kanagawa, 228-8522, Japan
Received:

17 August 2009

Accepted:

24 November 2009

Published online:

8 January 2010

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Abstract

The aim of this study was to investigate changes in the treatment strategy of rheumatoid arthritis (RA) and the prevalence of RA-related surgeries after approval of biologics in Japan and to analyze the impact of biologics on the incidence of orthopedic surgeries using a nationwide observational cohort database of rheumatic diseases [National Database of Rheumatic Diseases by iR-net in Japan (NinJa)]. The proportion of patients using biologics linearly increased from 2004 (1.8%) to 2007 (10.0%), but neither the number nor type of RA-related surgery significantly changed during this period. Patients treated with biologics exhibited relatively more severe disease activity and lower physical function. Among patients using biologics, those who underwent RA-related surgeries exhibited background characteristics of longer disease duration and worse physical function, while disease activity was not different from patients without surgery. These results suggest that the potential value of biologics in avoiding surgical procedure is limited in patients with severe functional disorders caused by long disease duration. Further investigation with a longer observation period is required to obtain more definite conclusions as to the impact of biologics usage on orthopedic surgeries.

Key words

Rheumatoid arthritis - Surgery - Biologics - MHAQ - Cohort study