A case with life-threatening interstitial pneumonia associated with bucillamine treatment
Yuiko Ogiwara1 , Hideaki Mochizuki1 , Takehiko Morioka2 , Takahiko Sugihara3 , Fumihiko Makino1 , Hideki Takahashi1
10 March 2008
17 April 2008
28 May 2008
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We report a case of bucillamine-induced interstitial pneumonia accompanied by severe hypoxemia in an 83-year-old woman who had rheumatoid arthritis. Respiratory failure worsened even after withdrawal of bucillamine and administration of high-dose corticosteroids, and mechanical ventilation was required. A review of 15 cases with bucillamine-induced pulmonary injury suggests that advanced age may be associated with the development of severe interstitial pneumonia. Bucillamine can cause corticosteroid-resistant and life-threatening lung injury, especially in the elderly.
Bucillamine - Elderly - Interstitial pneumonia - Lung injury - Rheumatoid arthritis