Vol.18 No.5

Case Report

Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review

Authors

Mitsuteru Akahoshi1,4 , Kumiko Aizawa1 , Shuji Nagano1 , Hisako Inoue1,2 , Atsushi Sadanaga1 , Yojiro Arinobu1 , Hiroaki Niiro1 , Hitoshi Nakashima1,3

  • Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
  • Department of Internal Medicine, Saga University School of Medicine, Saga, 849-8501, Japan
  • Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
  • Department of Internal Medicine, Chihaya Hospital, 2-30-1 Chihaya, Higashi-ku, Fukuoka, 813-8501, Japan
Received:

12 February 2008

Accepted:

15 April 2008

Published online:

13 June 2008

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Abstract

We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.

Key words

Acquired hemophilia - Factor VIII inhibitor - Systemic lupus erythematosus - Bleeding