Vol.18 No.4

Case Report

A case of granuloma in the occipital lobe of a patient with Wegener’s granulomatosis

Authors

Naoto Azuma1,2 , Yoshinori Katada2 , Nobumasa Nishimura3 , Tomonori Yamada3 , Ryunosuke Uranishi3 , Shinichi Nakatsuka4 , Makoto Dehara5 , Yoshinori Harada2 , Takao Yamanaka2 , Yukihiko Saeki6

  • Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
  • Division of Allergy and Clinical Immunology, National Hospital Organization Osaka-Minami Medical Center, 2-1 Kido-Higashi-machi, Kawachinagano, Osaka, 586-8521, Japan
  • Division of Neurosurgery, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan
  • Department of Pathology, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan
  • Division of Neurosurgery, Rinku General Medical Center, Izumisano, Osaka, Japan
  • Department of Clinical Investigation, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan
Received:

28 November 2007

Accepted:

10 March 2008

Published online:

19 April 2008

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Abstract

We report a case of Wegener’s granulomatosis (WG) with central nervous system (CNS) involvement in a woman who complained of bilateral visual disturbance. The intracranial necrotizing granulomatous lesion was confirmed by MR imaging and brain biopsy. After highdose oral corticosteroid treatment, not only clinical manifestations but also laboratory tests improved. Moreover, the CNS lesion completely regressed. This suggests that highdose corticosteroid alone might be effective in treating WG with CNS involvement.

Key words

Central nervous system involvement - High-dose corticosteroid therapy - Intracranial granuloma - MR imaging - Wegener’s granulomatosis