A case of planned pregnancy with an interruption in infliximab administration in a 27-year-old female patient with rheumatoidfactor- positive polyarthritis juvenile idiopathic arthritis which improved after restarting infliximab and methotrexate

Vol.18 No.2

Case Report

Authors

Yasuhito Nerome¹ , Hiroyuki Imanaka¹ , Yukiko Nonaka¹ , Yumiko Tsuru¹ , Nobuaki Maeno¹ , Tomoko Takezaki¹ , Hirosumi Mori¹ , Harumi Akaike¹ , Tomohiro Kubota¹ , Yoshifumi Kawano¹ , Syuji Takei¹

Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

Received:

13 August 2007

Accepted:

24 October 2007

Published online:

15 February 2008

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Abstract

We report a 27-year-old case of juvenile idiopathic arthritis (JIA) having been stopped infliximab during pregnancy. She was safely treated by infliximab therapy with premedications for preventing infusin reactions after her delivery, and then improved in the same manner as when she had been treated with infliximab therapy before pregnancy. As a result, it remains unclear whether or not we can use infliximab to control disease activities during pregnancy. In addition, it is also important to clarify whether or not premedications should be used when resuming infliximab treatment in such patients after pregnancy. These problems still remain controversial. More definitive data are needed in order to allow rheumatologists to better select the optimal TNF-alpha inhibitor therapy when treating pregnant JIA patients.

Key words

Pregnancy - Infliximab - Juvenile idiopathic arthritis