CASE REPORT
Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis
Authors
Isao Matsushita1, Miwa Uzuki2, Hiroaki Matsuno3, Eiji Sugiyama4 and Tomoastu Kimura1
| (1) |
Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan |
| (2) |
Department of Pathology I, School of Medicine, Iwate Medical University, Iwate, Japan |
| (3) |
Matsuno Clinic for Rheumatic Diseases, Toyama, Japan |
| (4) |
Department of Internal Medicine I, Faculty of Medicine, University of Toyama, Toyama, Japan |
Received:
May 23, 2006
Accepted:
August 7, 2006
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Abstract
We report a 62-year-old man with rheumatoid arthritis (RA) who developed nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.
Key words
Immunohistochemical staining, Matrix metalloproteinase (MMP), Methotrexate (MTX), Rheumatoid arthritis (RA), Rheumatoid nodulosis
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