CASE REPORT
Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis
Authors
Toshiro Sugimoto1, Mariko Soumura1, Kiichiro Danno2, Kenzo Kaji3, Miki Kondo3, Kunio Hirata1,
Jun Nakazawa1, Takashi Uzu1, Yoshihiko Nishio1 and Atsunori Kashiwagi1
| (1) |
Department of Medicine, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan |
| (2) |
Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan |
| (3) |
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan |
Received:
27 April 2006
Accepted:
15 June 2006
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Abstract
We have encountered a 68-year-old Japanese woman with limited cutaneous systemic sclerosis who developed de novo onset of accelerated hypertension and renal dysfunction; thus we diagnosed scleroderma renal crisis. Anticentromere antibody alone was identified, and not anti-DNA topoisomerase I antibody, anti-RNA polymerase antibodies, anti-Th/To antibodies, or antiribonucleoprotein antibodies, even with use of immunoprecipitation assay. She was successfully treated with angiotensin-converting enzyme inhibitor. This case, scleroderma renal crisis with detection of anticentromere antibody, is thought to be extremely uncommon.
Key words
Anticentromere antibody - Limited cutaneous systemic sclerosis - Scleroderma renal crisis
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