CASE REPORT
Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa
Authors
Yoshinori Katada1, Yoshinori Harada1, Naoto Azuma1, Kengo Matsumoto1, Haruko Terada2, Eriko Kudo3, Masaru Ishii3, Hiroyuki Yamane2, Suguru Yamamoto2, Shiro Ohshima4, Toru Mima3, Toshio Tanaka5 and Yukihiko Saeki1
| (1) |
Division of Allergy and Clinical Immunology, National Hospital Organization, Osaka-Minami Medical Center, 2-1 Kido-higashi, Kawachinagano 586-8521, Japan |
| (2) |
Division of Respiratory Disease, National Hospital Organization, Osaka-Minami Medical Center, Kawachinagano, Japan |
| (3) |
Division of Rheumatology, National Hospital Organization, Osaka-Minami Medical Center, Kawachinagano, Japan |
| (4) |
Division of Clinical Investigation, National Hospital Organization, Osaka-Minami Medical Center, Kawachinagano, Japan |
| (5) |
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Suita, Japan |
Received:
21 December 2005
Accepted:
18 May 2006
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Abstract
A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP). Neither myeloperoxidase- nor proteinase-3-antineutrophil cytoplasmic antibody was positive. These manifestations met the American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Stopping minocycline led to amelioration of symptoms and normalization of CRP level. To our knowledge, this is the second case of minocycline-induced vasculitis satisfying the criteria. Differential diagnosis for drug-induced disease is invaluable even for patients with classical polyarteritis nodosa.
Key words
Drug induced - Minocycline - Polyarteritis nodosa - Adverse effects
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