CASE REPORT
Reactive hemophagocytic syndrome in a case of systemic lupus erythematosus that was diagnosed by detection of hemophagocytosing macrophages in peripheral blood smears
Authors
Kiyofumi Hagiwara1 , Masakazu Sawanobori2, Yasunori Nakagawa2, Takeo Sato1, Osamu Akiyama1 and Tamiko Takemura3
| (1) |
Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan |
| (2) |
Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan |
| (3) |
Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan |
Received:
28 November 2005
Accepted:
20 March 2006
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Abstract
A 38-year-old woman with pancytopenia and liver dysfunction was diagnosed with active systemic lupus erythematosus (SLE). On days 9 and 10 of admission, peripheral blood smears showed macrophages phagocytosing platelets, and reactive hemophagocytic syndrome (HPS) was diagnosed. Hemophagocytic syndrome was successfully treated with high-dose prednisolone therapy and one course of methylprednisolone pulse therapy. Detection of hemophagocytosing macrophages in peripheral blood smears would be a useful and noninvasive method of diagnosing SLE-associated HPS.
Key words
Cytokine - Hemophagocytic syndrome (HPS) - Hemophagocytosis - Peripheral blood smear - Systemic lupus erythematosus (SLE) |
