CASE REPORT
Expansion of large granular lymphocytes following Pseudomonas infection in a patient with adult-onset Still's disease
Authors
Rie Tabata1 , Chiharu Tabata2, Hiromi Fukuda3 and Hiroyuki Kotani4
| (1) |
Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi, Amagasaki 661-0012, Japan |
| (2) |
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan |
| (3) |
Department of Ophthalmology, Osaka Kita Japan Post Hospital, Osaka, Japan |
| (4) |
Department of Internal Medicine, Osaka Kita Japan Post Hospital, Osaka, Japan |
Received:
21 November 2005
Accepted:
14 February 2006
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Abstract
We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without any evidence of active viral activation, hemophagocytosis, or malignancies. The increased LGL cells were CD3(+)CD8(+), and disappeared promptly after the administration of antibiotics combined with prednisolone, with subsequent stabilization of her general condition.
Key words
Adult-onset Still's disease (AOSD) - Large granular lymphocytes (LGL) |
