CASE REPORT
Anaphylactic reaction to infliximab in two rheumatoid arthritis patients who had previously received infliximab and resumed
Fumiaki Sugiura1 , Toshihisa Kojima1, Michinari Oba1, Hiroki Tsuchiya1 and Naoki Ishiguro1
| (1) |
Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan |
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Abstract Here we report on two cases of anaphylactic reaction following infliximab infusion in patients with active rheumatoid arthritis (RA). Both individuals had received infliximab treatment during a clinical trial approximately 2 years prior to further therapy; subsequent infusion of this agent led to anaphylactic reactions in both cases. In light of these findings, we recommend that future treatments with infliximab in RA patients who have previously received this agent should be carefully monitored.
Key words Anaphylactic reaction - Human antichimeric antibody (HACA) - Infliximab - Rheumatoid arthritis (RA) |
