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MODERN RHEUMATOLOGY Vol.14 No.5
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A case of systemic lupus erythematosus with postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome and concomitant high phosphatidylserine-dependent anti-prothrombin antibody levels |
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Motohisa Yamamoto1, Masahiro Nojima1, Mikiko Ohara1, Chisako Suzuki1, Yasuyoshi Naishiro1, Yoshiyuki Itoh1, Hiroyuki Yamamoto1, Hiroki Takahashi1, Yoshimori Kitajima2, Toshiaki Endo2 and Kohzoh Imai1 |
(1) First Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1-West 16, Chuo-ku, Sapporo 060-8543, Japan
(2) Department of Obstetrics, Sapporo Medical University, School of Medicine, Sapporo, Japan |
Received: 07 January 2004 Accepted: 31 May 2004 |
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Abstract |
| In August 1994, a 19-year-old woman presented to her dermatologist with a slight fever, arthralgia, and a butterfly rash. Discoid lupus erythematosus was suspected, and serological testing yielded positive results for antinuclear antibody. She was diagnosed with systemic lupus erythematosus without organ failure and was treated with only nonsteroidal antiinflammatory drugs. She became pregnant in June 2001, at age 26. In November her obstetrician noted that she had severe hypertension, edema of the low limbs, and proteinuria. On admission, she was diagnosed with severe preeclampsia, and cesarean section was performed. On hospital day 3 the patient developed sudden epigastric pain and vomiting. Laboratory tests revealed thrombocytopenia, liver dysfunction, and microangiopathic hemolytic anemia, leading to a diagnosis of HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. Plasma exchange was performed for 5 days. The thrombocytopenia, liver dysfunction, and proteinuria diminished quickly. Later testing revealed a high titer of plasma phosphatidylserine-dependent anti-prothrombin antibody. This case is useful for exploring the relations between SLE, HELLP syndrome, and anti-prothrombin antibody. |
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| Key words |
| Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome - Phosphatidylserine-dependent anti-prothrombin antibody - Plasma exchange - Preeclampsia - Systemic lupus erythematosus (SLE) |
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