A case of acquired hemophilia caused by factor VIII inhibitor with rheumatoid arthritis, successfully treated with immunosuppressive treatment and recombinant activated factor VII
(1) Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan
(2) Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
Received: 04 September 2003 Accepted: 05 March 2004
We report the case of a patient who presented with acquired hemophilia associated with rheumatoid arthritis. The patient's factor VIII activity was less than 1% and factor VIII inhibitor was detected. Based on the blood analysis, the patient was diagnosed as having the factor VIII inhibitor. She was successfully treated with prednisolone, cyclophosphamide, and gammaglobulin to suppress the factor VIII inhibitor, and the administration of recombinant activated factor VII was effective in controlling severe bleeding episodes
Key words
Acquired hemophilia - Factor VIII - Intramuscular hemorrhage - Recombinant activated factor VII (rFVIIa) - Rheumatoid arthritis (RA)
