Cyclosporin-induced cortical blindness in a patient with dermatomyositis
Takuya Sawabe1 and Shinichi Imafuku1
(1) Department of Rheumatology, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, 1-9-6 Sendamachi, Naka-ku, Hiroshima, 730-8619, Japan
(2) Department of Dermatology, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan
Cyclosporin A (CsA) has various adverse effects including neurotoxicity. We report the case of a 49-year-old Japanese woman with dermatomyositis who showed CsA-induced cortical blindness. The patient demonstrated cortical blindness despite having a normal blood concentration of CsA. The risk factors of CsA-induced cortical blindness include the use of corticosteroids and vascular injury, which are frequently observed in patients with systemic autoimmune diseases. Clinicians should consider CsA neurotoxicity when using CsA for patients with systemic autoimmune diseases.
Key words
Cortical blindness - Cyclosporin A (CsA) - Dermatomyositis (DM)
