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MODERN RHEUMATOLOGY Vol.14 No.3
>MR14-3
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| A case of mixed connective tissue disease presenting with nephrotic syndrome |
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| Hiro Kuroda1 , Keita Ishii1, Yuji Negoro1, Hiroko Sugiyama1, Junko Inoue1, Chiga Ogurusu1, Takeshi Kikuchi1, Keisei Shimoe2 and Katsutoshi Sunami3 |
(1) Department of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama, 721-8581, Japan
(2) Department of Dermatology, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuyama, Japan
(3) Department of Orthopedic Surgery, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuyama, Japan |
Received: 23 April 2003 Accepted: 03 February 2004 |
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Abstract |
| A 70-year-old woman was admitted to our hospital for the treatment of diffuse scleroderma and marked edema in the lower extremities. Renal biopsy revealed membranous change, interstitial nephritis, and intimal hyperplasia of the small arteries. The patient was diagnosed as having mixed connective tissue disease (MCTD) presenting with nephrotic syndrome (NS). She responded well to a combination treatment consisting of methylprednisolone (m-PSL) pulse therapy, oral PSL, and cyclosporine A (CsA). We speculated on the actual pathogenesis of NS in this case of MCTD. |
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| Key words |
| Corticosterioid - Cyclosporine A (CsA) - Mixed connective tissue disease (MCTD) - Nephrotic syndrome (NS) |
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