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MODERN RHEUMATOLOGY Vol.14 No.1
>MR14-1
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| Reiters syndrome following intravesical bacille biliE de Calmette GuErin treatment for superficial bladder carcinoma: report of six cases |
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| Hideyuki Murata1, Yoshihiro Adachi1, Takehiko Ebitsuka1, Yusuke Chino1, Reiko Takahashi1, Taichi Hayashi1, Daisuke Goto1, Isao Matsumoto1, Akito Tsutsumi1, Hideyuki Akaza1 and Takayuki Sumida1 |
(1) Division of Rheumatology, Department of Internal Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan
(2) Department of Urology, University of Tsukuba, Tsukuba, Japan |
Received: 18 April 2003 Accepted: 08 August 2003 |
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Abstract |
| Abstract We report the cases of six patients who developed acute Reiters syndrome following intravesical bacille biliE de Calmette?GuErin (BCG) immunotherapy for superficial bladder cancer. After the third to eighth BCG intravesical injection, the patients developed conjunctivitis, aseptic urethritis, and polyarthritis consistent with a diagnosis of Reiters syndrome. HLA-B27 antigen was negative in five of the patients examined. Two of the patients responded to nonsteroidal anti-inflammatory drugs for polyarthritis, and the other four responded to steroids (prednisolone 5?10mg/day). The frequent use of intracavitary BCG may increase the incidence of BCG-induced Reiters syndrome. Further analysis of the relationship between HLA-B and -DR alleles and arthritis should shed light on the mechanism of BCG-induced Reiters syndrome. |
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| Key words |
| Key words Bladder carcinoma - Intravesical bacille biliE de Calmette?GuErin (BCG) - Reiters syndrome - Therapy |
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