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MODERN RHEUMATOLOGY Vol.13 No.4
>MR13-4
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BehCets disease associated with myelodysplastic syndrome with elevated levels of inflammatory cytokines
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| Hitoshi Hasegawa1 , Kikue Iwamasa1, Nobuaki Hatta2 and Shigeru Fujita1 |
(1) First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Onsen-gun, Ehime, 791-0295, Japan
(2) Koyo New Town Hospital, Hiroshima, Japan |
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| Received: 11 November 2002 Accepted: 21 April 2003 |
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| Abstract |
| We report the case of a 56-year-old Japanese woman with BehCets disease and myelodysplastic syndrome (MDS), who had a history of episodic high-grade fever, recurrent oral and genital ulcers, and erythema nodosum, during a 13-year period from 1989 to 2002. Bone marrow aspirates obtained in January 1995 showed refractory anemia with trisomy 8, a subtype of MDS. Her serum levels of soluble interleukin-2 receptor (IL-2R), interferon-, IL-1, IL-6, IL-8, and granulocyte?macrophage colony stimulating factor in the active state were higher than those in the inactive state, whereas those of tumor necrosis factor- and IL-10 did not increase even in the active state. In this case, it was speculated that a T-cell immune response might have been involved in the disease pathogenesis, and that the repeated febrile episodes might have been a manifestation of neutrophil hyperfunction induced by increased serum levels of inflammatory cytokines. |
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| Key words |
| BehCets disease - Cytokine - Fever - Myelodysplastic syndrome (MDS) - Trisomy 8 |
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